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Dosing, interactions, and contraindications, with citations in English and French.
Should I hold metformin before tomorrow’s contrast CT?
What’s the amoxicillin dose for a 4-year-old weighing 18 kg?
How far will fluconazole push the INR on warfarin?
Is nitrofurantoin safe in the first trimester?
Does apixaban need adjusting at an eGFR of 28?
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Threvix
A macrolide or doxycycline, for outpatient CAP without significant comorbidities.
Azithromycin 500 mg on day 1, then 250 mg daily for 4 days, is first-line1. Doxycycline is an equivalent alternative where macrolide resistance is a concern2. Reassess at 48–72 hours3.
References
- 1College of Family Physicians of CanadaGuideline body
- 2Duration of Antibiotic Therapy for Community-Acquired PneumoniaPrimary literature
- 3Outpatient Management of Mild CAP in Adults Without ComorbiditiesPrimary literature
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- AllergyPenicillin
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Should I hold metformin before tomorrow’s contrast CT?
Answer
No need to hold it.
At an eGFR of 30 or above, iodinated contrast does not require metformin to be withheld1. Below 30, withhold and recheck at 48 hours2.
General
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A 34-year-old woman with three weeks of fatigue, palpitations, and 4 kg of weight loss.
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Hyperthyroidism
Weight loss with preserved appetite, tremor, palpitations.
- 2
Anxiety disorder
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Can I keep the apixaban if I start clarithromycin?
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What about the same patient with an eGFR of 28, at 81?
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Asked mid-clinic.Answered in seconds.
Dosing, interactions, and contraindications at the point of care, with the references attached, in English and French.